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Moreover, TXA has a variety of formulations, vehicles, and regimens of treatment that increase the variability of the results and hinder a suitable evaluation of its role in melasma treatment [58]

As the integrity of subcellular membranes depends heavily on GP, which in turn depends on selenium, the mechanism of GP is at the Selenocystein site, in a Se - form at resting state

Tumor-reprogrammed cells (TRCs), characterized by stem-like properties, downregulate PCK2 expression to adopt a ferroptosis-resistant state, suggesting that TRCs evade radio- and chemotherapy by reducing ferroptosis susceptibility