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As of this writing: The FDA has not published formal reclassification guidance

Foundational NNMT Discoveries The foundational research establishing NNMT as a metabolic regulator and potential therapeutic target came from studies by Daniel Kraus and colleagues published in Nature in 2014, which demonstrated that NNMT expression is dramatically upregulated in adipose tissue of obese humans and diet-induced obese mice, and that genetic knockdown of NNMT in mice protected against diet-induced obesity and improved metabolic parameters

Additionally, it is recommended to eat a balanced diet rich in foods that contain vitamin B12, such as meat, fish, dairy products, and fortified cereals

Polycythemia vera, a rare blood disorder, where careful medical oversight is appropriate