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Chelation therapy accomplishes this with the aid of EDTA, which binds the heavy metals and calcium within the plasma

Importantly, BefA-mediated effects are independent of inflammatory cascades: administration of purified BefA or conditioned media enriched in BefA does not elevate pro-inflammatory cytokines and does not activate NF-B, JNK, or STAT1 signaling

Together, these insights position FR as both a multifunctional regulator of cellular fate and a key molecular interface connecting folate metabolism, brain development, and neurobehavioral outcomes

For a deeper look at the mechanism and clinical data, see our complete guide to what tesamorelin is and how it works