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Increased Arg metabolism via the iNOS pathway has been observed in CD, suggesting a link between Arg metabolism and CD-related inflammation

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In addition, sustained DAMP-mediated signalling can sustain NF- and inflammasome activation, sustaining elevated levels of inflammatory cytokines at all times because of elevated levels of basal inflammatory cytokines and their release even in the absence of any initiating cause, effectively relating pulmonary inflammation with systemic effects [35]

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