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Activation of XKR8 by caspase-3 triggers NET formation The signaling cascades that orchestrate NET formation are extremely intricate and not yet fully understood 15,26

Necroptosis, a regulated form of cell death primarily dependent on receptor-interacting protein kinase 3 and mixed lineage kinase domain-like, is characterized by widespread cytoplasm and organelle swelling, plasma membrane rupture and release of cell components into the microenvironment (118)