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When melanin is overproduced due to sun damage, hormonal shifts, acne scarring, or pollution, it results in dark spots, uneven patches, dull skin tone, and hyperpigmentation

Compared with the placebo group, older patients administered anti-inflammatory interventions showed significantly lower depressive symptom scores (SMD = 0.57, 95% CI = 0.98 to 0.15, p = 0.008

This pathological accumulation is capable of precipitating a spectrum of clinical symptoms, including liver damage, neurological abnormalities, cardiac and renal impairments, development of Kayser-Fleischer rings in the cornea and hemolytic anemia (69)

Interestingly, research is pointing to hypofunction (reduced) at the NMDA receptor in the prefrontal cortex