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doi:10.1016/j.jtauto.2021.100131

Nutritional Deficiencies: Deficiencies in vitamins such as Vitamin C, K, and iron can contribute to the appearance of dark circles

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RTqPCR revealed expression of the hepatic markers A1AT , AFP, ALB , and ASGR1 as well as genes enriched in the liver such as APOA2 , TDO2 and TTR and xenobiotic metabolism, cytochrome P450 ( CYP) 3A4 and CYP3A7 (Supplementary Fig