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Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood

10.1016/j.jep.2023.117169 143 WuS.LiZ.LiH.LiaoK

Upon severe DNA injury, overactivation of PARP-1 depletes the cellular stores of NAD + , an essential cofactor of the glycolytic pathway, the tricarboxylic acid cycle, and the mitochondrial electron transport chain (762, 769, 1227, 1243)