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10.1016/j.pnpbp.2007.11.020 42 ZeinaliM.Abbaspour-RavasjaniS.GhorbaniM.BabazadehA.SoltanfamT.SantosA

Even if we could specifically block the IGF-1R and not IR, unwanted effects may arise such as glucose dysregulation and diabetes due to the inhibition of hybrid IGF-1R/IR receptors