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This compound serves an essential function in lipid metabolism, particularly facilitating the transport of long-chain fatty acid molecules across the mitochondrial membrane into the matrix, where -oxidation occurs

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Metformin, through activation of the AMPK/PGC-1 cascade, reduces A and tau pathology, restores hippocampal neurogenesis, and improves recognition memory, thereby capturing the metabolic and neurogenic dimensions of exercise [252]