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Abstract Oxidative stress is recognized as both a causative and contributing factor in many human diseases

Immunol Lett 149(12):918 Zakrzewski W, Dobrzynski M, Szymonowicz M, Rybak Z (2019) Stem cells: past, present, and future

Hyperglycemia and dyslipidemia increase mitochondrial substrates, leading to mitochondrial dysfunction with excessive production of reactive oxygen species (ROS) and reactive carbonyls

These discrepancies might be explained and reconciled by recent studies, which demonstrated that after amino acid deprivation, the proteasome moves from its predominant location in the nucleus to the cytoplasm, promoting protein degradation in the cytoplasm and thereby supplying the amino acids necessary for cell survival