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Gene expression studies reveal modulation of 408 neuronal genes, including dramatic increases in OPRM1 (opioid receptor, up 1,294%), KCND1 (up 845%), and SLC8A2 (up 737%)

In the context of AD, fisetin has been shown to modulate inflammatory pathways and maintain cognitive function in AD transgenic mice (53) and to enhance memory and induce hippocampal long-term potentiation in rats (54)

Our experience working with research teams across peptide applications confirms this repeatedly: protocols that ignore timing, fasted-state requirements, or exercise synchronisation produce inconsistent results despite using identical compounds at identical doses

DOI: 10.1038/s41467-020-17648-w.