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J Nanobiotechnology 22(1):291

It was demonstrated that exercise causes an activation of mitogen-activated protein kinases (MAPKs: p38, ERK 1 and ERK 2), which in turn activates nuclear factor B (NF-B) in rat gastrocnemius muscle and consequently the expression of important enzymes associated with defense against ROS (SOD) and adaptation to exerciseendothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) [101,102,103]