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10.1016/j.neuint.2012.07.025 192 KimH

Although functional loss of SRs can result in hypercholesterolemia, which leads to atherosclerosis and heart disease, it has been shown that when the SR-B2 is exposed to modified LDL, it interacts with TLR4 and TLR6, resulting in NF-B activation and contributing to the inflammatory response associated with atherosclerosis and promoting necrotic lesions of plaques (163, 164)