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While D2C7 monotherapy has demonstrated prolonged survival and promoted disease control in some patients, its efficacy is constrained by the potent immunosuppressive microenvironment in GBM [682]

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The respective ligand was modeled into this density using pre-existing monomers in the CCP4 library for 1 , E-64c and E-64d and a custom ligand built using Coots ligand builder for (2 S ,3 S )- t -ES- a9 - b7 (ref

A5: Researchers generally store small-molecule research compounds in a cool, dry environment away from direct light, following their institutions chemical storage and handling protocols to maintain stability and integrity