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Antioxidants such as vitamin E, N-acetylcysteine (NAC), and melatonin have been investigated as adjunctive treatments for schizophrenia, where they can reduce oxidative stress damage and improve patients symptoms ( Summary The etiology of schizophrenia has not yet been clarified, and more and more studies have shown that schizophrenia is a progressive neurodevelopmental disorder, and multiple factors play a role in the onset and development of the disease

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Alteration of the redox balance is a key factor in HIV-1 pathogenicity, including neurotoxicity and dementia, depletion of CD4 + /CD8 + T cells, susceptibility to lung infections, and side effects of antiretroviral therapy 111

These include vitamins B2, B6, B12, folic acid, tri-methyl glycine (TMG) and zinc