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In this regard, it is interesting that IgG antibodies that show similar FcRn binding properties can have variable plasma half-lives due to differences in biophysical properties, such as pI and net charge, which affect cellular handling 83,84,85,86,87

Lizard, G., Rouaud, O., Demarquoy, J., Cherkaoui-Malki, M

The LC-MS/MS analysis ran for a total of 86.5 minutes following a gradient elution profile: 2% B from 05.5 min, 210% B between 5.5 and 25.5 min, 1025% B from 25.545.5 min, 2537% B over 45.555.5 min, and a ramp to 80% B from 55.585.5 min