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Nevertheless, some studies have proposed that the relaxation effect of 2-agonists might be directly mediated through the interaction of Gs with potassium channels on the plasma membrane of airway smooth muscle cells (i.e., cAMP independent pathway) 176,177 (Fig

doi:10.1002/jbt.21432 Harvey CJ, Thimmulappa RK, Singh A, Blake DJ, Ling G, Wakabayashi N, Fujii J, Myers A, Biswal S (2009) Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

Of 23 patients evaluated in this trial, only one achieved a partial response to treatment

The lack of defined genetic drivers in most patients limits the immediate applicability of precision gene-silencing approaches, necessitating a shift towards targeting convergent pathological pathways and developing biomarkers for patient stratification