glutathione ferroptosis DOJINDO LABORATORIES Ferroptosis in Human Diseases: Fundamental

Studies have explored conjugating ferroptosis inducers, such as RSL3 prodrugs or GPX4-targeting siRNA, to HER2 antibodies or their fragments (e.g., scFv), to construct siRNAantibody fusion nanosystems capable of recognizing and binding to the surface of HER2-positive cells, thereby triggering endocytosis and targeted intracellular drug release

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Unlike ordinary vitamin B12 (cyanocobalamin), mecobalamin is the form the body can use directly and transport well into nerve tissue , which is why it is used particularly for peripheral neuropathy nerve damage causing tingling, numbness, or pain in the hands and feet as well as for megaloblastic anaemia due to B12 deficiency

Interestingly, the entered HgCys complex hardly translocate towards the shoot but retained in the root cells (Figure 2B), suggesting that the Hg accumulation in the roots occupies most amount of Hg in the whole plants