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Rapamycin, which induces autophagy through the inhibition of mTORC1, and wortmannin, which inhibits autophagy through inhibition of phosphatidylinositol-3-kinase (PI3K), were used as controls (Powis et al., 1994

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2024), the ferroptotic cell death was confirmed by the reduced expression of GSH, GPX-4, ferritin heavy chain (FTH) and SQSTM1, while nuclear receptor coactivator4 (NCOA4) and LC3II/I were markedly upregulated