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It is commonly believed that hypothyroidism is a chronic condition without a definitive cure, necessitating a lifetime of management through thyroid medication such as levothyroxine

Using multidimensional 1 H 13 C nuclear magnetic resonance (NMR) spectroscopy and multiple reaction mode mass spectrometry (MRM-MS) we show that ALT can contribute up to 89% of the intracellular glutamate pool and that ALT-derived glutamate is incorporated into glutathione