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Role of tau protein in both physiological and pathological conditions

This avalanche of soluble protofibrils is often believed to be more toxic than the stable full length cross-beta fibrils owing to their membrane permeabilization capability and interaction with various cellular organelles (Winner et al., 2011)

Anti-infective therapy is still the primary treatment for CAP, but inappropriate use of antibiotics is common in older individuals, and older individuals are particularly susceptible to antibiotic-associated adverse effects