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doi: 10.1155/2022/7993579 118 AliAAliSAqilMImamSSAhadAQadirA

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This finding links 4HNE to ferroptosis, as evidenced by lipid peroxidation, iron accumulation, nuclear translocation of NRF2, decreased GPX4 protein levels, and increased expression of ferroptotic markers, confirming that 4HNE acts as an inducer of ferroptosis [54]

Emodin can suppress cell growth through inducing cell cycle arrest at G0/G1, S and G2/M stages, such as G0/G1 arrest in NSCLC cells via hyaluronan synthase 2 (HAS2)-mediated signaling [461], and S and G2/M phases arrest in liver cancer (Hep G2) cells [456]