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Irradiated wounds are common skin lesions encountered in medical practice, primarily resulting from radiotherapy for cancer-related radiation incidents [190]

These data suggest that ATF4 deficiency increases ROS levels in cells, but the accumulation of ROS has been shown to prevented by chelation of the iron internalized by cells, and the effects produced by ATF4 overexpression can be inhibited by sorafenib and erastin (76, 77)

Besides, some researchers have investigated the effects on sleep of a specific vasomotor task that activates the right parietal cortex and seems to be related to a synaptic potentiation mechanism, which supports the hypothesis of the activation of a local homeostatic process during sleep

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