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Brusa L, Versace V, Koch G, et al

Endocrine Endocrine dysfunction is frequently reported in patients receiving ICIs (5%-20%), with an average onset time within 12 weeks from treatment initiation, and higher incidence in patients receiving combination therapy compared with monotherapy

While native IGF-1 has a half-life of minutes and is tightly sequestered by binding proteins (IGFBPs), IGF-1 LR3 incorporates two critical modifications

HSP90 enhanced MSC viability and protected MSCs from apoptosis induced by serum deprivation and hypoxia by downregulating membrane TLR-4 and ErbB2 receptors to activate their downstream PI3K/Akt and ERK1/2 pathways [93]