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Phenotype screening directly targets disease phenotypes (such as viral replication inhibition) to assess drug activity, whereas TBDD first identifies molecular targets associated with the disease (such as key enzymes) before designing compounds to modulate their functions

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Ciriolo, M.R

The role of lithium in regulating biomarkers such as GSK-3 and AKT, as well as other intracellular signaling modulators, was identified and associated with blood lithium levels, particularly in relation to efficacy and adverse effects