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[DOI] [PMC free article] [PubMed] [Google Scholar] Droge W, Breitkreutz R

Reduces Melanin Production

Laboratory experiments have revealed that AS-IV reduces GSH levels, alters the size and structure of mitochondria in RPE cells, enhances cellular antioxidant capabilities to mitigate ferroptosis, and ultimately decreases high glucose-induced RPE cell death through the miR-138-5p/SIRT1/NFE2L2 pathway (Tang et al., 2022)