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At the preclinical level, there is increasing evidence that the endocannabinoid system may play a role in tumor growth, treatment resistance, and metastasis

In addition, inflammation is closely associated with oxidative stress, which are able to trigger a series of transcription factors such as Nrf2, NF-B1, and pro-inflammatory cytokines such as TNF-, resulting in the differential expression of inflammatory cytokines, chemokines, and anti-inflammatory molecules [7, 53]

Therefore, the need for normal breed-specific reference ranges has been emphasised for comparison of pathological changes caused by cardiac disorders." (9) Jacobson, J.H., et al., An echocardiographic study of healthy Border Collies with normal reference ranges for the breed

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