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10 Authors viewpoint about notable drawbacks and suggestions to mitigate them 10.1 Toxicity and environmental impact due to metal leaching, biodegradability, and cytotoxicity concerns Over time, the leaching of metal ions from metal-doped/metal-hybrid CDs is a must, considering that this limitation can cause significant environmental contamination and toxicity to aquatic organisms

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These two powerhouses create mutually beneficial effects that amplify their individual benefits

Consequently, many clinicians combine both therapies to achieve synergistic effects, particularly in complex or chronic tendon injuries