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Prodrome During prodrome, early, flu-like symptoms occur, including: a fever of 100.4F (38C) or above headache anxiety feeling generally unwell sore throat and a cough nausea and vomiting discomfort at the site of the bite Acute neurologic period During this stage, neurologic symptoms develop, including: confusion and aggression partial paralysis involuntary muscle twitching rigid neck muscles convulsions hyperventilation and difficulty breathing hypersalivation, or producing a lot of saliva frothing at the mouth fear of water, or hydrophobia hallucinations, nightmares, and insomnia priapism, or permanent erection, in males photophobia, or a fear of light Toward the end of this phase, breathing becomes rapid and inconsistent

Many patients who do not meet hypermobile EDS criteria and do not have clear evidence for another specific syndrome will meet criteria for hypermobility spectrum disorders