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(2004) Transfection of the human malaria parasite Plasmodium falciparum

Deregulated NF-B activation has been associated with cancer, neurodegenerative disorders, inflammatory diseases, and arthritis

Frova C

Low-level local ROS are significant because they regulate critical transcription factors (NFB/IB, Nrf2/KEAP1, AP-1, p53, HIF-1) and act as redox-signaling molecules in a variety of pathways involved in ensuring the maintenance of cellular homeostasis (MAPK/ERK, PTK/PTP, PI3K-AKT-mTOR)