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Furthermore, LRRK2 mutationsparticularly G2019Sare linked to disrupted mitochondrial dynamics, altered kinase activity, and aberrant autophagy (Franco et al., 2021

This results in decreased absorption of copper and, therefore, copper deficiency [153]

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Effect of Aging on NAD+ Levels NAD+ Biosynthetic Pathways Decline With Age The decline in NAD+ biosynthetic pathways in the course of aging could be a possible explanation for the reduction of NAD+ levels