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CKD stage was based on the estimated glomerular filtration rate (GFR), determined using the CKD-EPI equation

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70 , e491 (2019)

It is tempting to speculate that low vitamin C availability is necessary whenever cell metabolism must be downregulated, as in seeds or in the quiescent center of the root apical meristem, where AsA is apparently leashed by AsA oxidase ( via the demethylation of DNA and histone proteins catalyzed by TET dioxygenases has been reported (Young et al., 2015)