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Another combination, decursin and TNF-related apoptosis-inducing ligand (TRAIL), is a promising anticancer agent because it stimulates the production of reactive oxygen species (ROS) that specifically trigger the PERK/ATF4 axis of the endoplasmic reticulum stress signalling system, thus increasing TRAIL sensitivity in TRAIL-resistant Non-Small Cell Lung Cancer (NSCLC) cell lines in part through DR5 up-regulation

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Kumar A, Trefault N, Olaniran AO (2014) Microbial degradation of 2,4-dichlorophenoxyacetic acid: Insight into the enzymes and catabolic genes involved, their regulation and biotechnological implications

Kong et al., similarly uncovered synergy between a complex I inhibitor and a mito-antioxidant in cancer cells, suggesting their ability to reduce mitochondria-derived H 2 O 2 levels as a potential mechanism of action (28)