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Legius syndrome is of autosomal dominant transmission and is characterized by the presence of CaLS and/or freckles, which are occasionally associated with macrocephaly, lipomas, Noonan phenotype, and/or learning difficulties.23 Often, these patients meet sufficient pigmentary criteria for diagnosis of NF1, but in Legius syndrome the presence of Lisch nodules, neurofibromas, central nervous system tumors, and NF1 gene mutations are specifically excluded