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Externally introduced arginase analogs can inhibit T cells antitumor activity by reducing the arginine level in the tumor microenvironment, just as the tumor or immunosuppressive cells expressing arginase 1 can

Pyroptosis (inflammatory cell death) is a form of programmed cell death activated by inflammasomes, characterized by rapid rupture of the cell membrane and release of inflammatory mediators, playing a crucial role in clearing infections and promoting inflammatory responses [66]

The deficiency of glutathione leads to increased levels of oxidative stress, which might further lead to chronic diseases such as increased blood sugar levels and rheumatoid arthritis

Novartis Foundation symposium