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For instance, a pilot clinical trial involving individuals with knee osteoarthritis demonstrated that taking MSM contributed to a significant reduction in pain and improved physical function over a 12-week period compared to a placebo.(4) Another randomized controlled study supported these findings, showing that patients with knee OA who took MSM for 12 weeks experienced small but significant improvements in physical function and total symptom scores, though the clinical significance of these findings requires further investigation.(5) MSM has also been shown to help preserve cartilage and support the effectiveness of glucosamine and chondroitin, other key compounds found in cartilage and connective tissue.(1) With that said, MSM is not a replacement for proper medical diagnosis

5.4 Herbal medicines and natural bioactive compounds Herbal medicines and natural compounds have demonstrated significant therapeutic potential in the management of EDC due to their multi-component, multi-target, and multi-pathway synergistic effects

In general, anything that increases the rate of metabolism (e } : CS1 maint: DOI inactive as of February 2026 (link) "Alcohol, 'Asian glow' mutation may contribute to Alzheimer's disease, study finds"

Some antioxidants were found to sensitize cancer cells to normal cancer treatments and impart synergistic effects with standard radio- and chemotherapy [58,59,60, 82, 84, 89, 171,172,173]