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In this way, the PGE 2 -Cav1.3-PARP1 axis forms a self-reinforcing survival pathway in which inflammation promotes Ca 2+ influx, and Ca 2+ influx supports anti-apoptotic signaling, allowing ectopic cells to evade clearance and persist in hostile microenvironments ( Therefore, targeting Ca 2+ signaling, particularly Cav1.3, may represent a dual therapeutic strategy by restoring mitochondrial resilience while also normalizing uterine contractility and pain-related signaling

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We developed a wearable bracelet incorporating multi-array EMG, enabling patterns of forearm activity to be distinguished, and associated with functional modes or postures of the hand

Waypa et al., 2013), but mtROS production in fibroblasts increases in PH due to downregulation of the auxiliary protein subunit of complex I, NDUFS4 (Plecit-Hlavat et al., 2016)