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In planta mutations of the cherI gene resulted in clear phenotypes (e.g., reduced phospho- and choline levels in fully developed leaves and stunted growth), but supplying cherI mutant plants with exogenous choline did not rescue these strong phenotypes (28)

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They go on: "The high lifetime prevalence of syringomyelia raises concerns for the welfare of the CKCS breed and also suggests that eliminating the genetic risk factors for the disease by selective breeding may be difficult, because the heritability has previously been shown to be complex