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Future studies should prioritize (1) isolating and characterizing the active compounds within these botanicals, (2) elucidating their precise molecular targets (e.g., thyroid peroxidase, sodium-iodide symporter, cytokine signaling pathways), and (3) conducting well-designed controlled clinical trials to rigorously evaluate their safety and efficacy in human patients

Cluster 4 exhibits upregulation in energy metabolism pathways such as pyruvate metabolism, TCA cycle, and oxidative phosphorylation

Eczema was induced using lipopolysaccharide or a mixture of Staphylococcal enterotoxin B and house dust mite extract

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