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Tirzepatide is a sensitive peptide, and vigorous shaking can damage the molecules, potentially making the medication less effective

RIG-I also features an atypical RNA-dependent ATPase motor domain (helicase domain), consisting of two RecA domains (Hel1 and Hel2) and an alpha-helical insertion domain (Hel2i), connected by a V-shaped pincer motif, and a carboxy-terminal domain (CTD) [216]

Shaking introduces shear stress and can cause the delicate protein chains to denature and aggregate, rendering them useless