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10.1016/j.brainresbull.2019.01.019 393 ZhaoW.BeersD

In individuals with Alzheimer's disease (AD), pyramidal neurons show a significant decrease in mitochondrial DNA copy number (mtDNA-CN) compared to those without cognitive impairment (147)

In addition to inhibiting Ang-II production, ACEIs also dilate blood vessels and lower BP by inhibiting the kininase 2 enzymes and reducing bradykinin (BK) degradation