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PIONEER 1: Randomized clinical trial of the efficacy and safety of oral GLP1 monotherapy in comparison with placebo in patients with type 2 diabetes

Such an imbalance is responsible for severe damage to essential biomolecules, such as lipids (lipid peroxidation), proteins (oxidation and inactivation), and DNA (strand breakage and mutations), which is associated with the pathogenesis of numerous diseases, including cancer, neurodegenerative diseases, cardiovascular diseases, and the aging process [28]

This oversight could be explained in part by the higher expression of PrP in the nervous system while it is lower in other tissues, including the liver 36,37 , which is primarily affected by WD

Across multiple experimental settings, these agents demonstrate biologic activity involving angiogenesis, inflammatory modulation, fibroblast migration, and collagen remodeling