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BMC Nephrol 19:285

Safety, tolerability, systemic exposure, and metabolism of CRS3123, a methionyl-tRNA synthetase inhibitor developed for treatment of Clostridium difficile , in a phase 1 study

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In contrast, while salicylate-induced tinnitus models show significant astrocyte and microglial activation in the AC and medial geniculate body, including upregulation of GFAP and Iba1 alongside increased IL-1 expression (Xia et al., 2020), the causal dependence on microglial activation in this model remains less certainsome evidence suggests that salicylate-induced tinnitus may persist even when microglial activation is pharmacologically suppressed (Glia, 2015)