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Non-traditional therapeutic approaches such as gene therapy, cell therapy, drug combinations and nano-delivery in ferroptosis-mediated diseases are also presented

and Dooner, M.S

Iron overload-induced ferroptosis has been increasingly recognized as a critical contributor to the pathogenesis of multiple fibrotic diseases, including hepatic fibrosis [20], renal fibrosis [21], radiation-induced intestinal fibrosis [22], myocardial fibrosis [23], and PF [24]

The mice were intraperitoneally injected (i.p.) with D-gal at a dose of 500 mg/kg/day (0.1 mL/10 g) for 7 weeks, except for the mice in the CG who received an equal volume of 0.9% normal saline