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melanocortinbased peptide pt141

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Description

1014 It inhibits human SIRT1 and SIRT2 with IC 50 values of 56 and 59 M in vitro, respectively, 240 and reduces the expression of poorly differentiated markers -fetoprotein and glypican, and impairs cell migration in a dose-dependent manner

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Y.Acad Sci

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10.1016/j.bioactmat.2025.06.042 Bioact Mater

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Lee D, Huntoon K, Wang Y, Kang M, Lu Y, Jeong SD, Link TM, Gallup TD, Qie Y, Li X, Dong S, Schrank BR, Grippin AJ, Antony A, Ha J, Chang M, An Y, Wang L, Jiang D, Li J, Koong AC , Tainer JA, Jiang W, Kim BYS

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