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In the liver, actually, these conditions trigger lipid peroxidation by specific polyunsaturated fatty acids (PUFAs), along with the formation of highly reactive aldehyde products [e.g., malondialdehyde (MDA) and 4-hydroxy-2-non-enal (4-HNE)]

doi: 10.1038/s41698-022-00344-x

DNA mismatch repair

Moreover, psychological trauma compromises gut barrier function and increases inflammation through stress hormone signaling (Sherin and Nemeroff, 2011)