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10.1128/mBio.00221-18 6 AndreoneP.FiorinoS.CursaroC.GramenziA.MargottiM.Di GiammarinoL.et al

As of time of publication, all further trials were happening in China with no phase 2 or 3 trials active anywhere else

The protein was purified by Ni-NTA agarose affinity and size-exclusion chromatography, and then dialyzed against 50 mM potassium phosphate (pH 6.6) for use in NMR experiments

This ligand-receptor interaction induces JAK transphosphorylation, activating JAK, which then phosphorylates tyrosine residues on the receptor, forming the docking site for STAT proteins