The recommended dose of pemetrexed for injection for maintenance treatment of non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m 2 as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle until disease progression or unacceptable toxicity after four cycles of platinum-based first-line chemotherapy
Most rodent studies used: 10 micrograms/kg 100 micrograms/kg Administration routes varied by study: Intraperitoneal injection Subcutaneous injection Oral administration in drinking water Example reference: Sikiric et al., 2018 These dosages reflect controlled laboratory conditions and are not generalised outside experimental models
Actions of VIP in the body include: Vasodilation to assist in blood pressure regulation, GI tract epithelial cell secretion and blood flow increasing water and electrolytes in the GI tract, relaxation of intestinal smooth muscle, exerting a positive effect on hypothalamic kisspeptin neurons, hormone balancing, and aromatase inhibiting effect corrects estradiol, 25-OH Vitamin D, and testosterone in males, downregulation of th1 responses and controlling cytokine responses to restore immunoregulation, especially following infections by intracellular bacteria and viruses
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society , 19 (5), 426431
