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In healthy cells, this ratio is more than 100 but it drops to less than 10 in cells that are exposed to oxidative stress

16(5): e4145

R4VPL3-1 induces ferroptosis in cancer cells To identify the cellular pathways involved in R4VPL3-1-induced cell death, we performed transcriptional analysis using whole transcriptomic sequencing and compared A375R cells treated for two hours with 10 M VHL-r or 10 M R4VPL3-1 (Fig